癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-ADAMTS1 Antibody
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- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P97857 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for A disintegrin and metalloproteinase with thrombospondin motifs 1(ADAMTS1) detection. Tested with WB in Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 11504 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, 3.4.24.-, Adamts1 |
| Calculated MW | 105801 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Rat, Mouse |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. |
| Source | Eukaryota |
| Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse ADAMTS1(956-968aa KHYIDFCTLTQCS), different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Contains 1 disintegrin domain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Adamts1 |
|---|---|
| Function | Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1691-Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (PubMed:10930576, PubMed:9441751). Also cleaves COMP (By similarity). Has angiogenic inhibitor activity (By similarity). May play a critical role in follicular rupture (PubMed:10781075). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
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