癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Aquaporin 6 Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q13520 |
| Host | Rabbit |
| Reactivity | Human |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Aquaporin-6(AQP6) detection. Tested with WB, IHC-P in Human. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 363 |
|---|---|
| Other Names | Aquaporin-6, AQP-6, Aquaporin-2-like, Kidney-specific aquaporin, hKID, AQP6, AQP2L |
| Calculated MW | 29370 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat Western blot, 0.1-0.5 µg/ml, Human |
| Subcellular Localization | Cytoplasmic vesicle membrane ; Multi-pass membrane protein . |
| Source | Eukaryota |
| Protein Name | Aquaporin-6 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 6(264-282aa EPLKKESQPGSGAVEMESV). |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AQP6 (HGNC:639) |
|---|---|
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:8812490). Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability (By similarity). It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro (By similarity). |
| Cellular Location | Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WTY0}; Multi-pass membrane protein |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Aquaporin 6, kidney specific is a protein in humans that is encoded by the AQP6 gene. The aquaporins(AQPs) are a family of water-transporting proteins that facilitate osmotically driven water movement across cell plasma membranes. Among the seven human aquaporins cloned to date(AQPs 0-6), genes encoding the four most closely related aquaporins(AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus. Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have shown AQP6 to flicker rapidly between closed and open status.
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