癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GLUT12 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q8TD20 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 12(SLC2A12) detection. Tested with WB in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 154091 |
|---|---|
| Other Names | Solute carrier family 2, facilitated glucose transporter member 12, Glucose transporter type 12, GLUT-12, SLC2A12, GLUT12, GLUT8 |
| Calculated MW | 66966 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse |
| Subcellular Localization | Endomembrane system ; Multi- pass membrane protein . Cytoplasm, perinuclear region . Localizes primarily perinuclear region in the absence of insulin. |
| Tissue Specificity | Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. . |
| Source | Eukaryota |
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 12 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human GLUT12(256-272aa SLKDEYQYSFWDLFRSK), identical to the related mouse and rat sequences. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC2A12 (HGNC:18067) |
|---|---|
| Function | Insulin-independent facilitative glucose transporter. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BFW9}; Multi-pass membrane protein. Endomembrane system {ECO:0000250|UniProtKB:Q5J316}; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily perinuclear region in the absence of insulin. |
| Tissue Location | Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Solute carrier family 2, facilitated glucose transporter member 12, also known as SLC2A12, is a protein that in humans is encoded by the SLC2A12 gene. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. By genomic sequence analysis, this gene is mapped to chromosome 6q23.2. SLC2A12 was detected in a perinuclear location in MCF7 cells in the absence of insulin; however, SLC2A12 redistributed to the plasma membrane of MCF7 cells grown continuously in the presence of insulin. This gene acts as facilitative glucose transporter.
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