癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Solute Carrier Family 22 Member 5 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q9Z0E8 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Solute carrier family 22 member 5(SLC22A5) detection. Tested with WB in Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 20520 |
|---|---|
| Other Names | Solute carrier family 22 member 5, High-affinity sodium-dependent carnitine cotransporter, Organic cation/carnitine transporter 2, Slc22a5, Octn2 |
| Calculated MW | 62780 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Mouse, Rat |
| Subcellular Localization | Apical cell membrane ; Multi-pass membrane protein . Colocalizes with PDZK1 on apical membranes of kidney proximal tubules. |
| Tissue Specificity | Widely expressed. Expressed in kidney, liver and testis. . |
| Source | Eukaryota |
| Protein Name | Solute carrier family 22 member 5 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse Solute carrier family 22 member 5(531-547aa KQWQIQSQTRMQKDGEE), different from the related rat sequence by two amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Slc22a5 {ECO:0000312|MGI:MGI:1329012} |
|---|---|
| Function | Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:20722056). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Basal cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O76082}. Note=Colocalizes with PDZK1 on apical membranes of kidney proximal tubules (PubMed:15523054) In intestinal cells, apical expression is induced by TNF (PubMed:20722056). |
| Tissue Location | Widely expressed. Expressed in kidney, liver and testis (PubMed:11010964). Expressed at the brush border of the small, large intestine and colon (at protein level) (PubMed:11010964, PubMed:20722056). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Solute carrier family 22(organic cation/carnitine transporter), member 5, also called SLC22A5 or OCTN2 is a membrane transport protein associated with primary carnitine deficiency. This gene is mapped to 5q31.1. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency(CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.
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