癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-HYAL1 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q91ZJ9 |
| Host | Rabbit |
| Reactivity | Mouse |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Hyaluronidase-1(HYAL1) detection. Tested with WB in mouse. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 15586 |
|---|---|
| Other Names | Hyaluronidase-1, Hyal-1, 3.2.1.35, Hyaluronoglucosaminidase-1, Hyal1 |
| Calculated MW | 52109 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Mouse |
| Subcellular Localization | Secreted . Lysosome . |
| Tissue Specificity | Highly expressed in liver, kidney, lung and skin. . |
| Source | Eukaryota |
| Protein Name | Hyaluronidase-1 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1(434-450aa LKDRAQMAMKFRCRCYR), different from the related rat sequence by one amino acid. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the glycosyl hydrolase 56 family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Hyal1 |
|---|---|
| Function | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. |
| Cellular Location | Secreted. Lysosome. |
| Tissue Location | Highly expressed in liver, kidney, lung and skin. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
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