癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-CAT1 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P30825 |
| Host | Rabbit |
| Reactivity | Human |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for High affinity cationic amino acid transporter 1(SLC7A1) detection. Tested with WB in Human. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 6541 |
|---|---|
| Other Names | High affinity cationic amino acid transporter 1, CAT-1, CAT1, Ecotropic retroviral leukemia receptor homolog, Ecotropic retrovirus receptor homolog, ERR, Solute carrier family 7 member 1, System Y+ basic amino acid transporter, SLC7A1, ATRC1, ERR, REC1L |
| Calculated MW | 67638 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human |
| Subcellular Localization | Cell membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Ubiquitous. . |
| Source | Eukaryota |
| Protein Name | High affinity cationic amino acid transporter 1 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human CAT1(613-629aa LDADQARTPDGNLDQCK), different from the related mouse and rat sequences by four amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC7A1 (HGNC:11057) |
|---|---|
| Function | High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q09143}; Multi-pass membrane protein |
| Tissue Location | Ubiquitous.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
High affinity cationic amino acid transporter 1, also called solute carrier family 7(cationic amino acid transporter, y+ system), member 1(SLC7A1) or ATRC1 is a protein that in humans is encoded by the SLC7A1 gene. This gene is mapped to 13q12.3. It acts as a cationic amino acid transporter and as an ecotropic retrovirus receptor and plays a role in the Na+-independent y+ cationic amino acid transport system. This gene is high-affinity, low capacity permease involved in the transport of the cationic amino acids(arginine, lysine and ornithine) in non-hepatic tissues.
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