癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-FHL3 Picoband Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q13643 |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Four and a half LIM domains protein 3(FHL3) detection. Tested with WB in Human;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 2275 |
|---|---|
| Other Names | Four and a half LIM domains protein 3, FHL-3, Skeletal muscle LIM-protein 2, SLIM-2, FHL3, SLIM2 |
| Calculated MW | 31192 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human, Rat |
| Tissue Specificity | Expressed only in skeletal muscle. |
| Source | Eukaryota |
| Protein Name | Four and a half LIM domains protein 3 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human FHL3 (41-84aa AECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQD), identical to the related mouse sequence. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins. |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FHL3 |
|---|---|
| Synonyms | SLIM2 |
| Function | Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9R059}. Cytoplasm {ECO:0000250|UniProtKB:Q9R059} |
| Tissue Location | Expressed only in skeletal muscle. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene. The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
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