癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-PTOV1 Antibody
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q86YD1 |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Prostate tumor-overexpressed gene 1 protein(PTOV1) detection. Tested with WB in Human;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 53635 |
|---|---|
| Other Names | Prostate tumor-overexpressed gene 1 protein, PTOV-1, Activator interaction domain-containing protein 2, PTOV1, ACID2 |
| Calculated MW | 46869 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Rat, Human |
| Subcellular Localization | Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts. |
| Tissue Specificity | Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine. . |
| Source | Eukaryota |
| Protein Name | Prostate tumor-overexpressed gene 1 protein |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human PTOV1 (385-414aa NFVNGIRRVIANQQQVLQRNLEQEQQQRGM), different from the related mouse and rat sequences by one amino acid. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTOV1 |
|---|---|
| Synonyms | ACID2 |
| Function | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. |
| Cellular Location | Cytoplasm. Nucleus. Cell membrane. Cytoplasm, perinuclear region. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase (PubMed:12598323). Also localizes to lipid rafts (PubMed:15713644). |
| Tissue Location | Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Prostate tumor overexpressed gene 1 protein is a protein that in humans is encoded by the PTOV1 gene. It is mapped to 19q13.33. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants.
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