Anti-LRP1/Lrp 1 Cluster Ii Rabbit Monoclonal Antibody

Western blot analysis of LRP1 expression in A549 cell lysate.
All lanes use the Antibody at 1:3W dilution for 1 hour at room temperature.
Immunohistochemical analysis of paraffin-embedded human liver carcinoma, using LRP1 Antibody.
Immunohistochemical analysis of paraffin-embedded Human pituitary tumor, using the Antibody at 1:300 dilution.
Immunohistochemical analysis of paraffin-embedded Human prostate cancer, using the Antibody at 1:300 dilution.
Immunohistochemical analysis of paraffin-embedded Human breast cancer, using the Antibody at 1:300 dilution.
Immunofluorescent analysis using the Antibody at 1:50 dilution.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC, IF, ICC, IP, FC
Primary Accession	Q07954
Host	Rabbit
Isotype	Rabbit IgG
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Format	Liquid
Description	Anti-LRP1/Lrp 1 Cluster Ii Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Additional Information
Gene ID	4035
Other Names	Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1 (HGNC:6692), A2MR, APR
Calculated MW	504606 Da
Application Details	WB 1:10000-1:20000 IHC 1:50-1:100 ICC/IF 1:50-1:100 IP 1:30 FC 1:50
Subcellular Localization	Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.
Tissue Specificity	Most abundant in liver, brain and lung.
Source	Eukaryota
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names	Clone: BDC-12
Immunogen	A synthesized peptide derived from human LRP1
Purification	Affinity-chromatography
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	LRP1 (HGNC:6692)
Synonyms	A2MR, APR
Function	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371).
Cellular Location	[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein Membrane, coated pit [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Tissue Location	Most abundant in liver, brain and lung.