癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-UCHL3 Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P15374 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-UCHL3 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 7347 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase isozyme L3, UCH-L3, 3.4.19.12, Ubiquitin thioesterase L3, UCHL3 |
| Calculated MW | 26183 Da |
| Application Details | WB 1:1000-1:2000 |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, and testis.. |
| Source | Eukaryota |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: BGE-21 |
| Immunogen | A synthesized peptide derived from human UCHL3 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | UCHL3 {ECO:0000303|PubMed:19047059, ECO:0000312|HGNC:HGNC:12515} |
|---|---|
| Function | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins (PubMed:19154770, PubMed:21762696, PubMed:22689415, PubMed:2530630). Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8 (PubMed:19154770, PubMed:21762696, PubMed:22689415, PubMed:2530630, PubMed:9790970). Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:19154770, PubMed:21762696, PubMed:22689415, PubMed:2530630). Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurodegenerative disorders (By similarity). Involved in DNA repair via homologous recombination (HR) by mediating deubiquitination of RAD51 in response to DNA damage, promoting interaction between RAD51 and BRCA2 (PubMed:27941124). Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling (By similarity). Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis (By similarity). Required for stress-response retinal, skeletal muscle and germ cell maintenance (By similarity). May be involved in working memory (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in heart, skeletal muscle, and testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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