Anti-AGTR2/Angiotensin Ii Type 2 Receptor Rabbit Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IP
Primary Accession	P50052
Host	Rabbit
Isotype	Rabbit IgG
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Format	Liquid
Description	Anti-AGTR2/Angiotensin Ii Type 2 Receptor Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.

Additional Information
Gene ID	186
Other Names	Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2 receptor, AGTR2 {ECO:0000303\|PubMed:7790004, ECO:0000312\|HGNC:HGNC:338}
Calculated MW	41184 Da
Application Details	WB 1:1000-1:2000 IP 1:50
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine..
Source	Eukaryota
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names	Clone: FIO-1
Immunogen	A synthesized peptide derived from human AGTR2
Purification	Affinity-chromatography
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	AGTR2 {ECO:0000303\|PubMed:7790004, ECO:0000312\|HGNC:HGNC:338}
Function	Receptor for angiotensin II, a vasoconstricting peptide (PubMed:28379944, PubMed:29967536, PubMed:31899086, PubMed:8185599). Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706).
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:P35374}; Multi-pass membrane protein
Tissue Location	In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine