Anti-ErbB (HER3) Rabbit Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IP
Primary Accession	P21860
Host	Rabbit
Isotype	Rabbit IgG
Reactivity	Rat, Human
Clonality	Monoclonal
Format	Liquid
Description	Anti-ErbB (HER3) Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human, Rat.

Additional Information
Gene ID	2065
Other Names	Receptor tyrosine-protein kinase erbB-3, 2.7.10.1, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Calculated MW	148098 Da
Application Details	WB 1:500-1:2000 IP 1:30
Subcellular Localization	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Epithelial tissues and brain.
Source	Eukaryota
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names	Clone: BIB-5
Immunogen	A synthesized peptide derived from human ErbB (HER3)
Purification	Affinity-chromatography
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	ERBB3
Synonyms	HER3
Function	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location	Epithelial tissues and brain.