癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-KDM5A Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IF, ICC, IP, FC |
|---|---|
| Primary Accession | P29375 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-KDM5A Monoclonal Antibody . Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse. |
| Gene ID | 5927 |
|---|---|
| Other Names | Lysine-specific demethylase 5A, 1.14.11.67, Histone demethylase JARID1A, Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, RBBP-2, [histone H3]-trimethyl-L-lysine(4) demethylase 5A, KDM5A (HGNC:9886) |
| Calculated MW | 192095 Da |
| Application Details | WB 1:500-1:2000 ICC/IF 1:100-1:500 IP 1:80 FC 1:200 |
| Source | Eukaryota |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AEHC-11 |
| Immunogen | A synthesized peptide derived from human KDM5A/Jarid1A/RBBP2 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KDM5A (HGNC:9886) |
|---|---|
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). |
| Cellular Location | Nucleus, nucleolus. Nucleus {ECO:0000250|UniProtKB:Q3UXZ9} Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250|UniProtKB:Q3UXZ9} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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