癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti- CD28 Monoclonal Antibody
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- 背景知识
Application 
| IHC-P |
|---|---|
| Primary Accession | P31041 |
| Host | Mouse |
| Isotype | Mouse IgG1, κ |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Anti- CD28 Monoclonal Antibody . Tested in IHC-P applications. This antibody reacts with Mouse. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500 µg/ml. |
| Gene ID | 12487 |
|---|---|
| Other Names | T-cell-specific surface glycoprotein CD28, CD28, Cd28 |
| Calculated MW | 25243 Da |
| Application Details | Immunohistochemistry (Paraffin-embedded Section), 2-5 µg/ml, Mouse |
| Source | Eukaryota |
| Protein Name | T-cell-specific surface glycoprotein CD28 |
| Contents | PBS, pH 7.0. Contains no stabilizers or preservatives |
| Clone Names | Clone: AGOA-3 |
| Immunogen | A20 cells expressing mouse CD28 and a recombinant mouse CD28-Ig fusion protein |
| Purification | Immunogen affinity purified. |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cd28 |
|---|---|
| Function | Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:7688139). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P10747} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co- stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). The CD28 gene is mapped to 2q33-q34. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.
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