癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-C4 Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IF, ICC |
|---|---|
| Primary Accession | P0C0L4 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-C4 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF applications. This antibody reacts with Human. |
| Gene ID | 720;721 |
|---|---|
| Other Names | Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2 |
| Calculated MW | 192785 Da |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 |
| Source | Eukaryota |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 17C85 |
| Immunogen | A synthesized peptide derived from human C4 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | C4A {ECO:0000303|PubMed:6546707, ECO:0000312|HGNC:HGNC:1323} |
|---|---|
| Function | Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. |
| Cellular Location | Secreted. Synapse Cell projection, axon. Cell projection, dendrite [Complement C4b-A]: Secreted. Cell surface. Note=Covalently associated with the surface of pathogens: the internal thioester bond reacts with carbohydrate antigens on the target surface to form amide or ester bonds. |
| Tissue Location | Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen (PubMed:11367523). The extra-hepatic sites of expression may be important for the local protection and inflammatory response (PubMed:11367523). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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