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Anti-Thromboxane synthase Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P24557 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Thromboxane synthase Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse. |
| Gene ID | 6916 |
|---|---|
| Other Names | Thromboxane-A synthase, TXA synthase, TXS, 5.3.99.5, Cytochrome P450 5A1, Hydroperoxy icosatetraenoate dehydratase, 4.2.1.152, TBXAS1, CYP5, CYP5A1 {ECO:0000303|PubMed:11465543}, TXAS |
| Calculated MW | 60518 Da |
| Application Details | WB 1:500-1:2000 |
| Source | Eukaryota |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 24T21 |
| Immunogen | A synthesized peptide derived from human Thromboxane synthase |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TBXAS1 |
|---|---|
| Synonyms | CYP5, CYP5A1 {ECO:0000303|PubMed:1146554 |
| Function | Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12- HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:22735388, PubMed:9873013). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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