癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPHKAP Antibody
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q2M3C7 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 186456 Da |
| Gene ID | 80309 |
|---|---|
| Positive Control | Western blot: Jurkat Cell lysate |
| Application & Usage | Western blot: 1-4 µg/ml. |
| Other Names | A-kinase anchor protein SPHKAP, SPHK1 interactor, AKAP domain containing, DKFZp781H143, DKFZp781J171, KIAA1678, MGC132614 antibody, MGC132616, SKIP antibody, A-kinase anchor protein Sphingosine kinase type 1-interacting protein, SPHK1 (Sphingosine kinase type 1) interacting protein, SPHK1-interactor and AKAP domain-containing protein, SPHK1 interactor, AKAP domain. |
| Target/Specificity | SPHKAP |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 30 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | SPHKAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SPHKAP |
|---|---|
| Synonyms | KIAA1678, SKIP |
| Function | Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. |
| Cellular Location | Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm |
| Tissue Location | Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
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