癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-HER2 (Trastuzumab), humanized Antibody
Human Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P04626. |
| Reactivity | Human |
| Host | CHO Cells |
| Clonality | Monoclonal |
| Isotype | Human IgG1ĸ |
| Application & Usage | Neutralization : 1-20 µg/ml; ELISA: 2 µg/ml |
|---|---|
| Alias Symbol | HER2 |
| Other Names | Herceptin, ErbB2 |
| Target/Specificity | Trastuzumab is a humanized IgG1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, HER2. |
| Appearance | Colourless liquid |
| Formulation | 100 ug (2mg/ml) of antibody in Phosphate buffered saline, pH 7.4. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-HER2 (Trastuzumab), humanized Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Trastuzumab is a recombinant humanized monoclonal immunoglobulin G1 kappa antibody that binds with high affinity and specificity to the extracellular domain of the HER2 receptor. A growth factor receptor gene, human epidermal growth factor receptor (HER2), is amplified in 25 to 30 % of breast cancers and in these cases the encoded protein is present in abnormally high levels in the malignant cells. Trastuzumab is used to treat adjuvant and metastatic breast cancer as well as metastatic gastric cancer.
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