癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-RAB24 Antibody
Rabbit Polyclonal antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q969Q5 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23124 Da |
| Gene ID | 53917 |
|---|---|
| Positive Control | WB: HeLa, RAW264.7, H92 cell lysates; IHC: human breast cancer tissue |
| Application & Usage | WB; 1:500 – 1:2000, IHC; 1:50 – 1:200 |
| Alias Symbol | RAB24 |
| Other Names | Ras-related protein Rab-24 |
| Formulation | In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide |
| Reconstitution & Storage | 12 months under -20°C |
| Background Descriptions | |
| Precautions | Anti-RAB24 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RAB24 (HGNC:9765) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction. |
| Cellular Location | Cytoplasm, cytosol. Membrane; Lipid-anchor Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P35290}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P35290}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P35290}. Note=Only about 20% is recovered in the particulate fraction (PubMed:10660536). RAB24 localizes in perinuclear region and in the limiting membranes of autophagic compartments under basal conditions. RAB24 is localized in the cytoplasm with an accumulated distribution in nuclear region at germinal vesicle (GV) stage of oocyte meiotic progression. At pre-metaphase I stage, localized in the cytoplasm with a particular concentration around chromosomes. As the oocytes enter metaphase I, located to the spindle region. Similar distribution pattern is observed in MII oocytes (By similarity). {ECO:0000250|UniProtKB:P35290, ECO:0000269|PubMed:10660536} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking. May be involved in autophagy-related processes
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