癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-USP6NL Antibody
Rabbit Polyclonal antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q92738 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 94104 Da |
| Gene ID | 9712 |
|---|---|
| Positive Control | WB: Jurkat, RAW264.7, PC12 lysates; IHC: human breast cancer tissue |
| Application & Usage | WB; 1:500 – 1:2000, IHC; 1:50 – 1:200 |
| Alias Symbol | USP6NL |
| Other Names | KIAA0019, USP6 N-terminal-like protein, Related to the N-terminus of tre, RN-tre |
| Formulation | In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide |
| Reconstitution & Storage | 12 months under -20°C |
| Background Descriptions | |
| Precautions | Anti-USP6NL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | USP6NL (HGNC:16858) |
|---|---|
| Synonyms | KIAA0019 |
| Function | Acts as a GTPase-activating protein for RAB43, RAB5A and RAB30 (PubMed:11099046, PubMed:16086013, PubMed:17562788, PubMed:17684057). Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. |
| Cellular Location | Golgi apparatus. Cytoplasmic vesicle. |
| Tissue Location | Widely expressed.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
USP6 N-terminal-like protein acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. It is also involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex
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