癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-TGF-b1 Antibody (3D9)
Mouse Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P01137 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1κ |
| Clone Names | 3D9 |
| Calculated MW | 44325 Da |
| Gene ID | 7040 |
|---|---|
| Application & Usage | WB: HepG2 cell lysate |
| Other Names | Transforming growth factor beta-1, TGF-beta-1, TGFB |
| Target/Specificity | TGF-b1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.02% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-TGF-b1 Antibody (3D9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFB1 (HGNC:11766) |
|---|---|
| Synonyms | TGFB |
| Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix |
| Tissue Location | Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TGF-β1 (transforming growth factor-beta) is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It also stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis.
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