CD105 Antibody

Mouse Monoclonal Antibody (Mab)

Immunohistochemical analysis of paraffin-embedded colorectal carcinoma; tissue using AD80042 performed on the Abcarta® FAIP-48 Fully automated IHC platform.Tissue was fixed with formaldehyde at room temperature, antigen retrieval was by heat mediation with a Citrate buffer (pH6. 0).Samples were incubated with primary antibody(Ready-to-use) for 15 min at room temperature. AmpSeeTM Detection Systems（Abcepta:ADR005） was used as the secondary antibody.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC
Primary Accession	P17813
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1
Clone Names	813A5D5
Calculated MW	70578 Da

Additional Information
Gene ID	2022
Gene Name	ENG
Other Names	Endoglin, CD105, ENG, END
Dilution	IHC~~Ready-to-use
Storage	Maintain refrigerated at 2-8°C.
Precautions	CD105 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	ENG
Synonyms	END
Function	Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830)