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>   首页   >   产品   >   免疫组化   >   免疫组化抗体   >   Cytomegalovirus   

Cytomegalovirus

Mouse Monoclonal antibody(Mab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P
Primary Accession P06725
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 325K2C7
Calculated MW 62898 Da
Additional Information
Other Names 65 kDa phosphoprotein, pp65, 65 kDa matrix phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83
Dilution IHC-P~~N/A
StorageMaintain refrigerated at 2-8°C.
Precautions Cytomegalovirus Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UL83
Function Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932).
Cellular Location Virion tegument. Host nucleus. Host cytoplasm. Note=As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection (PubMed:7815485). The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection (PubMed:17715235) Thereafter, pp65 is probably exported and accumulates in the cytoplasm (PubMed:17715235). Also found in dense bodies (PubMed:7815485)
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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