Cytomegalovirus
Mouse Monoclonal antibody(Mab)
- 产品详情
- 实验流程
Application ![]()
| IHC-P |
---|---|
Primary Accession | P06725 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 325K2C7 |
Calculated MW | 62898 Da |
Other Names | 65 kDa phosphoprotein, pp65, 65 kDa matrix phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83 |
---|---|
Dilution | IHC-P~~N/A |
Storage | Maintain refrigerated at 2-8°C. |
Precautions | Cytomegalovirus Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UL83 |
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Function | Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932). |
Cellular Location | Virion tegument. Host nucleus. Host cytoplasm. Note=As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection (PubMed:7815485). The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection (PubMed:17715235) Thereafter, pp65 is probably exported and accumulates in the cytoplasm (PubMed:17715235). Also found in dense bodies (PubMed:7815485) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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