CD35

Rabbit Monoclonal antibody(Mab)

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	P17927
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Clone Names	463M9T2
Calculated MW	223663 Da

Additional Information
Gene ID	1378
Gene Name	CR1
Other Names	Complement receptor type 1, C3b/C4b receptor, CD35, CR1, C3BR
Dilution	IHC-P~~Ready-to-use
Storage	Maintain refrigerated at 2-8°C.
Precautions	CD35 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CR1
Synonyms	C3BR
Function	Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
Cellular Location	Membrane; Single- pass type I membrane protein
Tissue Location	Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes