Claudin18.2

Rabbit Monoclonal antibody(Mab)

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	P56857
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Clone Names	451I3V0
Calculated MW	28122 Da

Protein Information
Name	Cldn18
Function	Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (PubMed:24588076). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (PubMed:24787463). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (PubMed:29400695). Acts as a negative regulator of RANKL- induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (PubMed:22437732). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (PubMed:23299504).
Cellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in epithelial cells. [Isoform A2.1]: Cell junction, tight junction. Lateral cell membrane
Tissue Location	Expressed in the lung (at protein level). [Isoform A1.2]: Expressed in lung. [Isoform A2.2]: Expressed in stomach.