癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-KPNA3 / IPOA4 Antibody (C-term), Biotinylated
- 产品详情
- 实验流程
Application 
| WB, IHC, IF, ICC, E, IP |
|---|---|
| Primary Accession | O00505 |
| Other Accession | 3839, NP_002258.2, 16648, 361055 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Human, Mouse, Rat, Dog |
| Calculated MW | 57811 Da |
| Gene ID | 3839 |
|---|---|
| Other Names | protein sorting/ trafficking; transporter; NPC; importin |
| Dilution | WB~~1:1000 IHC~~1:100~500 IF~~1:50~200 ICC~~N/A E~~N/A IP~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-KPNA3 / IPOA4 Antibody (C-term), Biotinylated is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KPNA3 |
|---|---|
| Synonyms | QIP2 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitous. Highest levels in heart and skeletal muscle |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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