癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Goat Anti-ASCL1 (aa79-91) Antibody
Purified Goat Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | P50553 |
| Other Accession | NP_004307.2, 429, 17172 (mouse), 64186 (rat) |
| Reactivity | Mouse, Rat |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 25454 Da |
| Gene ID | 429 |
|---|---|
| Other Names | ASCL1; achaete-scute complex homolog 1 (Drosophila); ASH1; HASH1; MASH1; bHLHa46; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute homolog 1; class A basic helix-loop-helix protein 46 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-HKSAPKQVKRQRS, from the internal region of the protein sequence according to NP_004307.2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ASCL1 (aa79-91) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASCL1 (HGNC:738) |
|---|---|
| Function | Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q02067}. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H.
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