Goat anti-IL6R / CD126 (isoform 1) Antibody

Peptide-affinity purified goat antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Pep-ELISA
Primary Accession	P08887
Other Accession	NP_000556.1
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Clone Names	IL6R
Calculated MW	51548 Da

Additional Information
Gene ID	3570
Other Names	IL6R; interleukin 6 receptor ; HGNC:6019; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991 ; CD126 antigen; interleukin 6 receptor alpha subunit
Dilution	Pep-ELISA~~N/A
Format	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen	This antibody is expected to recognise isoform 1 only (NP_000556.1)
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	Goat anti-IL6R / CD126 (isoform 1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	IL6R (HGNC:6019)
Function	Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, PubMed:31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans- signaling'. Alternatively, 'cluster signaling' occurs when membrane- bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).
Cellular Location	[Isoform 1]: Cell membrane {ECO:0000250\|UniProtKB:P22272}; Single-pass type I membrane protein [Soluble interleukin-6 receptor subunit alpha]: Secreted
Tissue Location	[Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820).