Goat anti-SSP29 / ANP32B, Biotinylated Antibody

Peptide-affinity purified goat antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC, Pep-ELISA
Primary Accession	Q92688
Other Accession	NP_006392.1
Reactivity	Human, Mouse, Rat, Pig, Dog, Bovine
Host	Goat
Clonality	Polyclonal
Clone Names	ANP32B
Calculated MW	28788 Da

Additional Information
Gene ID	10541
Other Names	ANP32B; acidic nuclear phosphoprotein 32 family member B; APRIL; PHAPI2; SSP29; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic protein rich in leucines; putative HLA-DR-associated protein I-2; silver-stainable protein SSP29
Dilution	WB~~1:1000 IHC~~1:100~500 Pep-ELISA~~N/A
Format	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen	This antibody does NOT recognize theTNF family member also known as APRIL - Gene ID number 8741. However this antibody may cross-react with ANP32A (GeneID 8125).
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	Goat anti-SSP29 / ANP32B, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	ANP32B
Synonyms	APRIL, PHAPI2
Function	Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity).
Cellular Location	[Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase.
Tissue Location	Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.