癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Goat anti-Adipogenin (mouse) Antibody
Peptide-affinity purified goat antibody
- 产品详情
- 实验流程
Application 
| Pep-ELISA |
|---|---|
| Primary Accession | Q8R400 |
| Other Accession | NP_663610.1 |
| Reactivity | Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | Adig |
| Calculated MW | 9362 Da |
| Gene ID | 246747 |
|---|---|
| Other Names | Adig; adipogenin; SMAF-1; Smaf1; small adipocyte factor 1 |
| Dilution | Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-Adipogenin (mouse) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Adig {ECO:0000303|PubMed:41196993, ECO:0000312|MGI:MGI:2675492} |
|---|---|
| Function | Key regulator of lipid storage that promotes the expansion of lipid droplets during the formation of mature adipocytes (PubMed:16132694, PubMed:33691105, PubMed:41196993). Acts by forming a dodecameric complex with seipin (BSCL2) when adipocytes have differentiated and are undergoing maturation (PubMed:41196993). In the dodecameric complex, ADIG antagonizes the activity of BSCL2 by reducing BSCL2-mediated triacylglycerol nucleation and relieving BSCL2's inhibition of GPAT3 and GPAT4 (PubMed:41196993). GPAT3 and GPAT4 then translocate to lipid droplets, promoting the synthesis of triacylglycerols and the expansion of lipid droplets (PubMed:41196993). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus |
| Tissue Location | Selectively expressed in adipose tissue where it is particularly enriched in brown adipose tissue (PubMed:15567149, PubMed:16132694). In adipose tissue, expressed exclusively in adipocytes and not in the stromal-vascular cell population (PubMed:15567149, PubMed:16132694). Expressed at much lower levels in heart, stomach and muscle and barely detected in kidney and lung (PubMed:15567149, PubMed:16132694). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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