Goat anti-TRPV5, Biotinylated Antibody

Peptide-affinity purified goat antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IF, ICC, Pep-ELISA
Primary Accession	Q9NQA5
Other Accession	NP_062815.3
Reactivity	Human, Mouse, Rat, Pig, Dog, Bovine
Host	Goat
Clonality	Polyclonal
Clone Names	TRPV5
Calculated MW	82562 Da

Additional Information
Gene ID	56302
Other Names	TRPV5; transient receptor potential cation channel subfamily V member 5; CAT2; ECAC1; OTRPC3; calcium transport protein 2; calcium transporter 2; epithelial calcium channel 1; osm-9-like TRP channel 3; transient receptor potential cation channel, subfamil
Dilution	WB~~1:1000 IF~~1:50~200 ICC~~N/A Pep-ELISA~~N/A
Format	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	Goat anti-TRPV5, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	TRPV5
Synonyms	ECAC1 {ECO:0000303\|PubMed:10945469}
Function	Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
Cellular Location	Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity) The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590) {ECO:0000250\|UniProtKB:P69744, ECO:0000269\|PubMed:18768590}
Tissue Location	Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.