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>   首页   >   产品   >   一抗   >   其他   >   Goat anti-CSK, Biotinylated Antibody   

Goat anti-CSK, Biotinylated Antibody

Peptide-affinity purified goat antibody

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, Pep-ELISA
Primary Accession P41240
Other Accession NP_004374.1
Reactivity Human, Mouse, Rat, Dog, Bovine
Host Goat
Clonality Polyclonal
Clone Names CSK
Calculated MW 50704 Da
Additional Information
Gene ID 1445
Other Names CSK; c-src tyrosine kinase; C-Src kinase; protein-tyrosine kinase CYL
Dilution WB~~1:1000
IHC~~1:100~500
Pep-ELISA~~N/A
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Reported variants represent identical protein: NP_004374.1, NP_001120662.1
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat anti-CSK, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSK
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Cellular Location Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts
Tissue Location Expressed in lung and macrophages.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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