癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Goat anti-PTGR1 Antibody
Peptide-affinity purified goat antibody
- 产品详情
- 实验流程
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q14914 |
| Other Accession | NP_036344.2, NP_001139581.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | PTGR1 |
| Calculated MW | 35870 Da |
| Gene ID | 22949 |
|---|---|
| Other Names | PTGR1; prostaglandin reductase 1; LTB4DH; PGR1; ZADH3; 15-oxoprostaglandin 13-reductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; leukotriene B4 12-hydroxydehydrogenase; zinc binding alcohol dehydrogenase domain containing 3 |
| Dilution | WB~~1:1000 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_036344.2; NP_001139581.1). Reported variants represent identical protein: NP_036344.2, NP_001139580.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-PTGR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTGR1 |
|---|---|
| Synonyms | LTB4DH |
| Function | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15- oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15- oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q29073}. |
| Tissue Location | High expression in the kidney, liver, and intestine but not in leukocytes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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