癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Goat anti-BHLHE22 Antibody
Peptide-affinity purified goat antibody
- 产品详情
- 实验流程
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q8NFJ8 |
| Other Accession | NP_689627.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | BHLHE22 |
| Calculated MW | 36997 Da |
| Gene ID | 27319 |
|---|---|
| Other Names | BHLHE22; basic helix-loop-helix family, member e22; BHLHB5; Beta3; CAGL85; TNRC20; basic helix-loop-helix domain containing, class B, 5; class B basic helix-loop-helix protein 5; class E basic helix-loop-helix protein 22; trinucleotide repeat containing 2 |
| Dilution | WB~~1:1000 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-BHLHE22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BHLHE22 |
|---|---|
| Synonyms | BHLHB5, TNRC20 |
| Function | Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. |
| Cellular Location | Nucleus. |
| Tissue Location | Brain-specific, with the highest expression in the cerebellum. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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