癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Goat anti-LYP / PTPN22 Antibody
Peptide-affinity purified goat antibody
- 产品详情
- 实验流程
Application 
| IHC, IF, FC, Pep-ELISA |
|---|---|
| Primary Accession | Q9Y2R2 |
| Other Accession | NP_057051, NP_036543.4, NP_001180360.1, NP_001295226.1 |
| Reactivity | Human, Chimpanzee |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | PTPN22 |
| Calculated MW | 91705 Da |
| Gene ID | 26191 |
|---|---|
| Other Names | PTPN22; LYP; Lyp1; Lyp2; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase homolog; lymphoid-specific protein tyrosine phosphatase |
| Dilution | IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is specific for human LYP1 and will not cross-react with LYP2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-LYP / PTPN22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTPN22 |
|---|---|
| Synonyms | PTPN8 |
| Function | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P29352}. |
| Tissue Location | Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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