癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Goat anti-POU4F2 Antibody
Peptide-affinity purified goat antibody
- 产品详情
- 实验流程
Application 
| FC, Pep-ELISA |
|---|---|
| Primary Accession | Q12837 |
| Other Accession | NP_004566.2 |
| Reactivity | Human, Mouse, Rat, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | POU4F2 |
| Calculated MW | 43087 Da |
| Gene ID | 5458 |
|---|---|
| Other Names | POU4F2; POU class 4 homeobox 2; BRN3.2; BRN3B; Brn-3b; Brn3b POU domain transcription factor; POU domain class 4 transcription factor 2; POU domain protein; POU domain, class 4, transcription factor 2 |
| Dilution | FC~~1:10~50 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is not expected to cross-react to the similar POU4F3 (GeneID 5459) |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-POU4F2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POU4F2 (HGNC:9219) |
|---|---|
| Synonyms | BRN3B |
| Function | Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity). |
| Cellular Location | Nucleus. Nucleus speckle. Cytoplasm {ECO:0000250|UniProtKB:Q63934} |
| Tissue Location | Expressed in the brain (PubMed:7691107). Expressed in the ganglion cell layer of the retina (PubMed:7691107) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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