癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CRTC3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q6UUV7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5935 |
| Calculated MW | 66959 Da |
| Gene Name | CRTC3 |
| Aliases | CRTC3; CREB Regulated Transcription Coactivator 3; CREB-Regulated Transcription Coactivator 3; FLJ21868; TORC-3; TORC3; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3; Transducer Of Regulated CAMP Response Element-Binding Protein 3; Transducer Of Regulated CREB Protein 3; Transducer Of CREB Protein 3 |
| Immunogen | A synthesized peptide derived from CRTC3 |
| Gene ID | 64784 |
|---|---|
| Other Names | CREB-regulated transcription coactivator 3, Transducer of regulated cAMP response element-binding protein 3, TORC-3, Transducer of CREB protein 3, CRTC3, TORC3 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRTC3 |
|---|---|
| Synonyms | TORC3 |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Cellular Location | Nucleus. Cytoplasm. Note=Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118) |
| Tissue Location | Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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