癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-MCM6 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14566 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2005 |
| Calculated MW | 92889 Da |
| Gene Name | MCM6 |
| Aliases | MCM6; Minichromosome Maintenance Complex Component 6; Minichromosome Maintenance Deficient (Mis5, S. Pombe) 6; DNA Replication Licensing Factor MCM6; P105MCM; Mis5; MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae); MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe); Minichromosome Maintenance Deficient 6 Homolog (S. Cerevisiae); MIS5 Homolog (S.Pombe); EC 3.6.4.12; MCG40308; MIS5 |
| Immunogen | A synthesized peptide derived from human MCM6 |
| Gene ID | 4175 |
|---|---|
| Other Names | DNA replication licensing factor MCM6, 3.6.4.12, p105MCM, MCM6 (HGNC:6949) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MCM6 (HGNC:6949) |
|---|---|
| Function | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). |
| Cellular Location | Nucleus. Chromosome. Note=Binds to chromatin during G1 and detaches from it during S phase. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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