癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-LGI1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O95970 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5950 |
| Calculated MW | 63818 Da |
| Gene Name | LGI1 |
| Aliases | LGI1; Leucine Rich Glioma Inactivated 1; Epitempin-1; EPITEMPIN; IB1099; ETL1; EPT; Leucine-Rich Glioma-Inactivated Protein 1; Epilepsy, Partial; ADPAEF; ADPEAF; ADLTE |
| Immunogen | A synthesized peptide derived from human Lgi1 |
| Gene ID | 9211 |
|---|---|
| Other Names | Leucine-rich glioma-inactivated protein 1, Epitempin-1, LGI1, EPT |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LGI1 {ECO:0000303|PubMed:9879993, ECO:0000312|HGNC:HGNC:6572} |
|---|---|
| Function | Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (PubMed:15047712). |
| Cellular Location | Secreted. Synapse {ECO:0000250|UniProtKB:Q8K4Y5} Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1} [Isoform 2]: Endoplasmic reticulum. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1} |
| Tissue Location | [Isoform 1]: Expressed in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is between 3 and 5 times more abundant than in the hippocampus (at protein level) (PubMed:16787412). Expression is absent in the cerebellum (PubMed:16787412). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
