癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CLPX Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O76031 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5980 |
| Calculated MW | 69224 Da |
| Gene Name | CLPX |
| Aliases | Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X; ATP-Dependent Clp Protease ATP-Binding Subunit ClpX-Like, Mitochondrial; ClpX (Caseinolytic Protease X, E. Coli) Homolog ; ClpX Caseinolytic Protease X Homolog (E. Coli); Energy-Dependent Regulator Of Proteolysis; ClpX Caseinolytic Peptidase X Homolog; ClpX Caseinolytic Protease X Homolog; EPP2 |
| Immunogen | A synthesized peptide derived from human CLPX |
| Gene ID | 10845 |
|---|---|
| Other Names | ATP-dependent clpX-like chaperone, mitochondrial, 3.6.4.10, ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, Caseinolytic mitochondrial matrix peptidase chaperone subunit X {ECO:0000312|HGNC:HGNC:2088}, CLPX (HGNC:2088) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CLPX (HGNC:2088) |
|---|---|
| Function | ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation (PubMed:11923310, PubMed:22710082, PubMed:28874591). Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5- aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity (PubMed:22841477). |
| Cellular Location | Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid |
| Tissue Location | Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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