癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Histone deacetylase 10 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q969S8 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6050 |
| Calculated MW | 71445 Da |
| Gene Name | HDAC10 |
| Aliases | HDAC10; Histone Deacetylase 10; Polyamine Deacetylase HDAC10; DKFZP761B039; HD10; EC 3.5.1.; EC 3.5.1. |
| Immunogen | A synthesized peptide derived from human HDAC10 |
| Gene ID | 83933 |
|---|---|
| Other Names | Polyamine deacetylase HDAC10, 3.5.1.48, 3.5.1.62, Histone deacetylase 10, HD10, HDAC10 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HDAC10 |
|---|---|
| Function | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome- lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). |
| Cellular Location | Cytoplasm. Nucleus Note=Excluded from nucleoli. |
| Tissue Location | Widely expressed with high levels in liver and kidney. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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