癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-USP9X Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q93008 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6090 |
| Calculated MW | 290463 Da |
| Gene Name | USP9X |
| Aliases | USP9X; Ubiquitin Specific Peptidase 9 X-Linked; DFFRX; MRX99; FAF; Ubiquitin Specific Protease 9, X Chromosome (Fat Facets-Like Drosophila); Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X; Ubiquitin-Specific Protease 9, X Chromosome; Deubiquitinating Enzyme FAF-X; Ubiquitin Thioesterase FAF-X; Fat Facets In Mammals; HFAM; FAM; Ubiquitin Specific Peptidase 9, X-Linked (Fat Facets-Like, Drosophila); Ubiquitin Specific Protease 9, X-Linked (Fat Facets-Like, Drosophila); Ubiquitin-Specific Processing Protease FAF-X; Ubiquitin-Specific-Processing Protease FAF-X; Drosophila Fat Facets Related, X-Linked; Fat Facets Protein Related, X-Linked; Fat Facets Protein-Related, X-Linked; Ubiquitin Thiolesterase FAF-X; EC 3.4.19.12; EC 3.1.2.15; MRXS99F; XLID99; USP9 |
| Immunogen | A synthesized peptide derived from human USP9x |
| Gene ID | 8239 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 9X, 3.4.19.12, Deubiquitinating enzyme FAF-X, Fat facets in mammals, hFAM, Fat facets protein-related, X-linked, Ubiquitin thioesterase FAF-X, Ubiquitin-specific protease 9, X chromosome, Ubiquitin-specific-processing protease FAF-X, USP9X {ECO:0000303|PubMed:18254724, ECO:0000312|HGNC:HGNC:12632} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | USP9X {ECO:0000303|PubMed:18254724, ECO:0000312|HGNC:HGNC:12632} |
|---|---|
| Function | Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). Specifically hydrolyzes 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'- linked polyubiquitins chains (PubMed:30914461). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates RNA demethylase enzyme ALKBH5, promoting its stability (PubMed:37454738). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity). Inhibits the activation of the Hippo signaling pathway via deubiquitination of AMOTL2 at 'Lys-347' and 'Lys-408' which prohibits its interaction with and activation of LATS2. Loss of LATS2 activation and subsequent loss of YAP1 phosphorylation results in an increase in YAP1-driven transcription of target genes (PubMed:26598551, PubMed:34404733). |
| Cellular Location | Cytoplasm, cytosol. Cell projection, growth cone. Cytoplasm, cytoskeleton, cilium axoneme |
| Tissue Location | Widely expressed in embryonic and adult tissues. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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