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>   首页   >   KD-Validated Anti-Inhibin subunit beta B Rabbit Monoclonal Antibody   

KD-Validated Anti-Inhibin subunit beta B Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, ICC
Primary Accession P09529
Reactivity Human, Mouse
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 24GB6100
Calculated MW 45122 Da
Gene Name INHBB
Aliases INHBB; Inhibin Subunit Beta B; Inhibin Beta B Chain; Activin Beta-B Chain; Inhibin, Beta B (Activin AB Beta Polypeptide); Activin AB Beta Polypeptide; Inhibin Beta B Subunit; Inhibin, Beta B; Inhibin, Beta-2
Immunogen A synthesized peptide derived from human Inhibin beta B
Additional Information
Gene ID 3625
Other Names Inhibin beta B chain, Activin beta-B chain, INHBB

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name INHBB
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity).
Cellular Location Secreted.
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