癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Lysyl-tRNA synthetase 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q15046 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6130 |
| Calculated MW | 68048 Da |
| Gene Name | KARS1 |
| Aliases | KARS1; Lysyl-TRNA Synthetase 1; KARS2; KARS; Lysyl-TRNA Synthetase; Lysine--TRNA Ligase; Lysine TRNA Ligase; EC 6.1.1.6; DFNB89; LysRS; Deafness, Autosomal Recessive 89; EC 2.7.7.-; KIAA0070; EC 6.1.1; CMTRIB; DEAPLE; LEPID; KRS |
| Immunogen | A synthesized peptide derived from human LysRS |
| Gene ID | 3735 |
|---|---|
| Other Names | Lysine--tRNA ligase, 2.7.7.-, 6.1.1.6, Lysyl-tRNA synthetase, LysRS, KARS1 (HGNC:6215), KARS, KIAA0070 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KARS1 (HGNC:6215) |
|---|---|
| Synonyms | KARS, KIAA0070 |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). |
| Cellular Location | [Isoform Cytoplasmic]: Cytoplasm, cytosol. Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted Note=Secretion is induced by TNF (PubMed:15851690). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:23159739) |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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