癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-IMPDH2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P12268 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6135 |
| Calculated MW | 55805 Da |
| Gene Name | IMPDH2 |
| Aliases | IMPDH2; Inosine Monophosphate Dehydrogenase 2; IMP (Inosine 5'-Monophosphate) Dehydrogenase 2; Inosine-5'-Monophosphate Dehydrogenase Type II; Inosine-5'-Monophosphate Dehydrogenase 2; IMP Dehydrogenase II; EC 1.1.1.205; IMPDH-II; IMPDH 2; IMPD 2; IMPD2; IMP (Inosine Monophosphate) Dehydrogenase 2; Inosine Monophosphate Dehydrogenase Type II; Epididymis Secretory Sperm Binding Protein; Inosine 5' Phosphate Dehydrogenase 2; IMP Dehydrogenase 2; IMP Oxireductase 2 |
| Immunogen | A synthesized peptide derived from human IMPDH2 |
| Gene ID | 3615 |
|---|---|
| Other Names | Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, IMPD 2, IMPDH 2, 1.1.1.205, Inosine-5'-monophosphate dehydrogenase type II, IMP dehydrogenase II, IMPDH-II, IMPDH2 (HGNC:6053), IMPD2 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IMPDH2 (HGNC:6053) |
|---|---|
| Synonyms | IMPD2 |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion. |
| Tissue Location | IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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