癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-MGEA5 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O60502 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6120 |
| Calculated MW | 102915 Da |
| Gene Name | OGA |
| Aliases | OGA; O-GlcNAcase; NCOAT; MEA5; Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase; MGEA5; Meningioma Expressed Antigen 5 (Hyaluronidase); N-Acetyl-Beta-D-Glucosaminidase; Meningioma-Expressed Antigen 5; N-Acetyl-Beta-Glucosaminidase; Beta-N-Acetylglucosaminidase; Beta-N-Acetylhexosaminidase; Protein O-GlcNAcase; Beta-Hexosaminidase; Hyaluronidase In Meningioma; Bifunctional Protein NCOAT; EC 3.2.1.169; KIAA0679; HEXC |
| Immunogen | A synthesized peptide derived from human MGEA5 |
| Gene ID | 10724 |
|---|---|
| Other Names | Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610, ECO:0000305}, OGA, 3.2.1.169, Beta-N-acetylglucosaminidase, Beta-N-acetylhexosaminidase, Beta-hexosaminidase, Meningioma-expressed antigen 5, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase, Nuclear cytoplasmic O-GlcNAcase and acetyltransferase, NCOAT, OGA {ECO:0000303|PubMed:20863279, ECO:0000312|HGNC:HGNC:7056} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OGA {ECO:0000303|PubMed:20863279, ECO:0000312|HGNC:HGNC:7056} |
|---|---|
| Function | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta- GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). |
| Cellular Location | [Isoform 3]: Nucleus |
| Tissue Location | Ubiquitous. Shows highest expression in the brain, placenta and pancreas. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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