癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-MacroH2A.1 Histone Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | O75367 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB485 |
| Calculated MW | 39184 Da |
| Gene Name | MACROH2A1 |
| Aliases | MACROH2A1; MacroH2A.1 Histone; H2AFY; Medulloblastoma Antigen MU-MB-50.205; H2A Histone Family Member Y; Core Histone Macro-H2A.1; Histone MacroH2A1; Histone H2A.Y; MacroH2A1.2; H2A/Y; MH2A1; H2A Histone Family, Member Y; Histone MacroH2A1.1; Histone MacroH2A1.2; MACROH2A1.1; MACROH2A1.2; H2AF12M; H2A.Y |
| Immunogen | A synthesized peptide derived from human macroH2A.1 |
| Gene ID | 9555 |
|---|---|
| Other Names | Core histone macro-H2A.1, Histone macroH2A1, mH2A1, Histone H2A.y, H2A/y, Medulloblastoma antigen MU-MB-50.205, MACROH2A1 (HGNC:4740) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MACROH2A1 (HGNC:4740) |
|---|---|
| Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:15897469). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15897469). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16107708, PubMed:16428466). |
| Cellular Location | Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin (PubMed:15621527, PubMed:15897469, PubMed:9634239). Recruited to DNA damage sites in an APLF-dependent manner (PubMed:21211722, PubMed:29905837). |
| Tissue Location | Widely expressed.. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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