癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CSNK1E mouse monoclonal antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | P49674 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 25GB490 |
| Calculated MW | 47315 Da |
| Gene Name | CSNK1E |
| Aliases | CSNK1E; Casein Kinase 1 Epsilon; CKIepsilon; HCKIE; CKIE; Casein Kinase I Isoform Epsilon; EC 2.7.11.1; Casein Kinase 1, Epsilon; CKI-Epsilon; EC 2.7.11; CKIe |
| Immunogen | Recombinant protein of human CSNK1E |
| Gene ID | 1454 |
|---|---|
| Other Names | Casein kinase I isoform epsilon, CKI-epsilon, CKIe, 2.7.11.1, CSNK1E |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CSNK1E |
|---|---|
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle Expressed in monocytes and lymphocytes but not in granulocytes |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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