癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-FURIN Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P09958 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB2160 |
| Calculated MW | 86678 Da |
| Gene Name | FURIN |
| Aliases | FURIN; Furin, Paired Basic Amino Acid Cleaving Enzyme; PCSK3; SPC1; PACE; FUR; Paired Basic Amino Acid Residue-Cleaving Enzyme 3; Proprotein Convertase Subtilisin/Kexin 3; Subtilisin-Like Proprotein Convertase 1; EC 3.4.21.75; Furin; Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein); Furin (Paired Basic Amino Acid Cleaving Enzyme); Proprotein Convertase Subtilisin/Kexin Type 3; Furin, Membrane Associated Receptor Protein; Dibasic Processing Enzyme; Dibasic-Processing Enzyme; FES Upstream Region; EC 3.4.21 |
| Immunogen | A synthesized peptide derived from human Furin |
| Gene ID | 5045 |
|---|---|
| Other Names | Furin, 3.4.21.75, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN {ECO:0000303|PubMed:7690548, ECO:0000312|HGNC:HGNC:8568} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FURIN {ECO:0000303|PubMed:7690548, ECO:0000312|HGNC:HGNC:8568} |
|---|---|
| Function | Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:11799113, PubMed:9412467). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113) |
| Tissue Location | Seems to be expressed ubiquitously. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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