癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-AP2S1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P53680 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2980 |
| Calculated MW | 17018 Da |
| Gene Name | AP2S1 |
| Aliases | AP2S1; Adaptor Related Protein Complex 2 Subunit Sigma 1; CLAPS2; FBH3; Adaptor Related Protein Complex 2 Sigma 1 Subunit; Clathrin Assembly Protein 2 Sigma Small Chain; Plasma Membrane Adaptor AP-2 17 KDa Protein; Adaptor Protein Complex AP-2 Subunit Sigma; Clathrin Coat-Associated Protein AP17; Clathrin Coat Assembly Protein AP17; AP-2 Complex Subunit Sigma; HA2 17 KDa Subunit; Sigma2-Adaptin; Sigma-2; FBHOk; AP17; HHC3; Clathrin-Associated/Assembly/Adaptor Protein, Small 2 (17kD); Adaptor-Related Protein Complex 2 Subunit Sigma; Hypocalciuric Hypercalcemia 3 (Oklahoma Type); FBHOK |
| Immunogen | A synthesized peptide derived from AP2S1 |
| Gene ID | 1175 |
|---|---|
| Other Names | AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Adaptor-related protein complex 2 subunit sigma, Clathrin assembly protein 2 sigma small chain, Clathrin coat assembly protein AP17, Clathrin coat-associated protein AP17, HA2 17 kDa subunit, Plasma membrane adaptor AP-2 17 kDa protein, Sigma2-adaptin, AP2S1 (HGNC:565), AP17, CLAPS2 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AP2S1 (HGNC:565) |
|---|---|
| Synonyms | AP17, CLAPS2 |
| Function | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L- [LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non- clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P63010}. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV {ECO:0000250|UniProtKB:P63010} |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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